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BSIG Webinars Ep5 Take 2: Human disease research – A new frontier for system dynamics



Pharmaceutical research is universally acknowledged to be “too costly” (over $2 billion per new drug), “too long” (over a decade to market), and “too ineffective” (one in thousands of candidates make it). A big impediment to progress is the routine focus on narrow “silos” of research, largely ignoring the systems in which human diseases interact with the body. What if you could speed research by simulating long-term chronic systemic conditions in minutes, testing leverage points and combinations of interventions to identify the most likely successful therapies in advance of conventional (expensive) trials? Today, preclinical testing is on mice, pigs, monkeys… and the findings rarely translate well to humans. SD simulation offers important new opportunities to enhance our understanding of the systems of the body, and to identify far more effectively better treatments, even cures, for the most devastating diseases.

On today’s episode our guest Ken Cooper will 1) discuss years of SD work in modeling systems of the human body, focusing on the immune system, 2) describe the HIV analyses and the first clinical trial ever approved based on SD model analyses, 3) share observations from initial modeling of…

– Autoimmune disorders such as type 1 diabetes…What dynamics lie behind the relapsing-remitting course of T1D, MS, and other autoimmune